Marine biotoxins are natural metabolites (phycotoxins) produced by microalgae, mainly by dinoflagellates and diatoms. These compounds can be consequently accumulated in marine organisms that feed by filtering large volumes of water (such as shellfish used for human consumption) and enter into the food chain. Thus periodic sampling and routine monitoring programs have been developed to ensure consumer protection.
Traditionally, the presence of toxins has been determined using the mouse bioassay. However, the controversial issue of using mammals for testing, in addition to the limitations of bioassays encourage the development of alternative assays to detect marine toxins in seafood.
Methods development involves several analytical steps, as well as extractions, derivatizations, separations... In this section we offer custom-fitted toxic materials
- Dinoflagellates and/or shellfish extracts contaminated with desired toxin concentrations, established by quantitative analytical UPLC-MS procedures.
- Dinoflagellates extracts producing palytoxin-like compounds, quantified by qualitative/quantitative functional assays.
- PSP toxins that comprise an epimerization equilibrium can be provided as single epimer toxins or with custom-fitted epimerization ratios.
- Mixtures of toxins.
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