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Marine Toxins

Marine biotoxins are natural metabolites produced by micro-algae. Through accumulation in the food chain, these toxins may concentrate in different marine organisms, including filter-feeding bivalves, grazing organisms, herbivorous and predatory fishes.
Therefore harmful algal blooms (HABs) are naturally occurring events that are globally increasing in the last years and may lead to human poisoning due to ingestion of seafood contaminated by phycotoxins.
The accuracy of an analytical measurement is defined as the closeness of agreement between a test or measurement result and the true value. It usually requires calibration of the analytical method with a known standard. This is often done with standards of several concentrations to make a calibration or working curve.
The highest degree of confidence is achieved with Certified Reference Materials (CRMs), which are characterized by a metrologically valid procedure for one or more specified properties, accompanied by a certificate that provides the value of the specified property, its associated uncertainty, and a statement of metrological traceability, according to the definition stated in ISO Guide 30.
All the standards from our catalogue have been developed following the guidelines of ISO Guides Series 30. Therefore those standards included in CRMs Section have their concentrations certified. The analytical method used for quantification is 1H-qNMR; and assignment of the purity is based on combination of measurements from 1H-qNMR and liquid chromatography coupled to ESI-MS/MS. 
The batches obtained for standards defined as Quality Controlled Standards (QCSs) do not allow carrying out the  homogeneity/stability studies needed for certification, but they have been developed following the guidelines of ISO Guides Series 30, and the analytical method for quantification and assignment of purity is liquid chromatography coupled to ESI-MS/MS.
Approval catalogue Date:   Mar 2019
Approved by:   Laboratory Director